BREAKTHROUGH

Molecular Glues for the Selective Elimination

BREAKTHROUGH

FOR CHRONIC INFLAMMATION

of Pathogenic Macrophages

for CHRONIC INFLAMMATION

Molecular Glues for the Selective Elimination of Pathogenic Macrophages

OUR SCIENCE

EpiTET’s novel targets and molecular glue degrader approach selectively eliminates pathogenic macrophages, the key drivers of chronic inflammation and disease micro-environment without suppressing overall immunity.

KEY PUBLICATIONS

- TET-3-overexpressing macrophages promote endometriosis
- Targeting TET3 in macrophages provides a concept strategy for the treatment of endometriosis
- Let-7 suppresses liver fibrosis by inhibiting hepatocyte apoptosis and TGF-β production
- A Positive Feedback Loop of TET3 and TGF-β1 Promotes Liver Fibrosis

Our approach has the potential to revolutionize the way we treat a number of chronic inflammatory conditions including Endometriosis, Metabolic Disorders (MASH), Cancers, and other conditions.

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470 James Street #007

EpiTET Therapeutics, Inc.

New Haven, CT 06513

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